Platelets and proteases

Proteases and Anti-proteases: Molecular Mechanisms and Novel Therapeutic Targets

a,-Antitrypsin functions as a 'mousetrap ' to inhibit its target proteinase, neutrophil elastase. The common severe Z deficiency variant ( G ~ u ~ ~ ' + Lys) destabilizes the mousetrap to allow a sequential protein-protein interaction between the reactive-centre loop of one molecule and psheet A of another. These loop-sheet polymers accumulate within hepatocytes to form inclusion bodies that ar...

Functional assembly of intrinsic coagulation proteases on monocytes and platelets. Comparison between cofactor activities induced by thrombin and factor Xa

Generation of coagulation factor Xa by the intrinsic pathway protease complex is essential for normal activation of the coagulation cascade in vivo. Monocytes and platelets provide membrane sites for assembly of components of this protease complex, factors IXa and VIII. Under biologically relevant conditions, expression of functional activity by this complex is associated with activation of fac...

Proteases in the Brain Proteases in Biology and Disease

The source of HLA molecules on platelets: Does platelets adsorb soluble HLA molecules from their environment?

Background: The origin and function of human leukocyte antigen (HLA) class I molecules on platelets are still highly arguable. Given the differences in the results of the previous studies in this regard, the lack of research in recent years, and the clinical importance of HLA class I molecules, the absorption capacity of platelets for soluble HLA class I molecules was studied in this investigat...

PLATELETS AND THROMBOPOIESIS Anucleate platelets generate progeny

1Program in Human Molecular Biology and Genetics and 2Department of Surgery, University of Utah, Salt Lake City; 3Department of Nanoscale Imaging of Cellular Dynamics, Courant Research Centre Nano-Spectroscopy and X-Ray Imaging, University of Göttingen, Göttingen, Germany; 4Department of Physics and Harvard School of Engineering and Applied Sciences, Harvard University, Cambridge, MA; 5Division...